The Ten Books on Architecture, 1.4.10

Vitruvius  translated by Joseph Gwilt

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10That the salubrity of a tract of land is discovered by the pastures or food which it furnishes, is sufficiently clear, from certain qualities of the lands in Crete, situate in the vicinity of the river Pothereus, which lie between the two states of Gnosus and Gortyna. There are pasturages on each side of this river: the cattle, however, pastured on the Gnossian side, when opened, are found with their spleens perfect; whilst those on the opposite side, nearer to Gortyna, retain no appearance of a spleen. Physicians, in their endeavours to account for this singular circumstance, discovered a species of herb eaten by the cattle, whose property was that of diminishing the spleen. Hence arose the use of the herb which the Cretans call ἄσπληνος, as a cure for those affected with enlarged spleen.

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